Wellness is dynamic and multidimensional. We cannot understand wellness by alone examining biological phenomena and medical knowledge, but instead we must also consider a variety of social, political, economic, racial, gender, and cultural forces in which wellness and illness are produced and understood. Drawing upon literature, art, history, film, and health, in conjunction with a community engagement experiential component, we examine the history of and physical, social, emotional, intellectual, occupational, and spiritual components of wellness and illness from ancient times through the present.